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Ustekinumab : Information for Patients and Caregivers

Ustekinumab is also known by the brand name Stelara. It is used to treat moderate to severe active Crohn’s Disease and moderate to severe active Ulcerative Colitis in adults. It can be an option when certain other therapies including steroids, immunosuppressants (such as azathioprine, mercaptopurine, methotrexate) or biologic drugs such as anti-TNF’s infliximab, adalimumab or golimumab haven’t been effective. Or if other therapies have stopped working or you’ve experienced adverse events that are hard to manage.

Mechanism: The ustekinumab injection falls under the group of medications named ‘biological drugs’. These drugs are produced by a biological, rather than chemical, process. Ustekinumab is a synthetic (man-made) antibody that is created inside the living cells. It is mainly an anti-Interleukin biological drug. It targets a couple of proteins in the body named interleukin-12 (IL-12) and interleukin-23 (IL-23). IL-12 and IL-23 are the naturally produced in the body in order to help fight the infections by temporarily causing inflammation. IL-12 and IL-23 are increased in IBD and contribute to the ongoing, or chronic, inflammation in the digestive system. This medication binds to both IL-12 and IL-23 which prevents them from acting, helping to relieve inflammation and symptoms. It is known as an ‘immunosuppressant’ because it dampens down the mechanism of the immune system.

Duration of Treatment: Individuals responds differently when taking any new medication, and ustekinumab doesn’t work for everyone. You may feel good as early as 3 weeks after taking ustekinumab, but most individuals who respond to ustekinumab start feeling better within 6 weeks. In some cases it may take a bit take longer. In case you respond to treatment with ustekinumab and have no severe side effects, you may be put onto a planned course of therapy lasting up to a year, following which it can be extended. Your treatment plan will need to be reassessed at least every one year to see whether ongoing ustekinumab therapy is appropriate for you. In case you are in stable remission, it can be decided that you can stop taking ustekinumab dose. But If after stopping the treatment you become unwell again, you should have the option to restart. You may be taken off this.edication if you have any severe side effects or in case you have not responded well enough within 16 weeks of initiating your treatment.

Dosage: Ustekinumab comes in the pre-filled syringe containing 90 mg. It can’t be taken by mouth (in tablet form) because the digestive system would destroy it. The initial dose of ustekinumab is approximately 6 mg for every kg you weigh administeted as a drip into a vein in the arm, an intravenous (IV) infusion. All the following doses are 90 mg regardless of what your weight is, and these are all administered as an injection under the skin (subcutaneously).

Administration: The first dose of ustekinumab is administeted in hospital as a drip into a vein in your arm – an intravenous (IV) infusion. The next dose is administeted as an injection under the skin – a subcutaneous injection 8 weeks later. You will then have the further injections every 8 or 12 weeks. Your health specialist will decide whether you will need to take ustekinumab every 8 weeks or every 12 weeks. To begin with, a health specialist will give you the injections. Once you are used to having the treatment, they will teach you the technique so that you can easily self-inject. If you prefer, a family member or friend can be trained to administer the injections. 

Effect of Ustekinumab: Ustekinumab can be effective in order to improve symptoms and in bringing about and maintaining the remission in individuals with moderate to severe Crohn’s Disease and moderate to severely active UC. It means that the inflammation in the gut is effectively decreased and your symptoms go away or significantly improve. Taking the drug ustekinumab may also mean you no longer have to take steroids. Certain studies suggest ustekinumab may also be useful in treating perianal fistulating Crohn’s Disease. A perianal fistula connects the anal canal (back passage) to the surface of the skin just near the anus.

Checks Prior to Taking Ustekinumab: Before you start Ustekinumab treatment, it is crucial to make sure that it is right for you. Make sure the team treating you know: 

  • in case you have ever had an allergic reaction to ustekinumab or latex, or in case you are allergic to any of its other ingredients.  
  • in case you have any history of TB (tuberculosis) or any exposure to individuals with TB. You need not be given ustekinumab in case you have active TB. In case you have underlying, inactive TB, this must be treated prior to starting ustekinumab. 
  • in case you have a history of infections, have an ongoing infection or have symptoms such as feeling feverish or generally unwell. In case you’ve an infection your therapy may need to be postponed.
  • in case you are having or have ever had injections in order to treat the allergies. It is unknown if ustekinumab affects these.
  • in case you are pregnant, planning to get pregnant, or are breastfeeding.
  • in case you are taking or have recently taken any other drugs, including other biological drugs such as adalimumab or infliximab or immunosuppressive medicines such as mercaptopurine, methotrexate or azathioprine. 
  • in case you have recently had or will have any vaccinations.
Side Effects of Taking Ustekinumab: Like all drugs, ustekinumab can also have side effects, although not every individual experiences these. Some side effects may happen almost prompty, others may not appear for a few days, weeks or even longer. Some side effects are likely to be very mild and may go away on their own. Others could be severe and may need treatment. Side effects of ustekinumab include the following:
 
Immediate Reactions: These are not common, but some symptoms may mean that you are having an allergic reaction to ustekinumab. Report to your IBD team promptly in case you observe any of the following symptoms right follows you take ustekinumab, or in the days after an infusion or injection.
  • difficulty breathing or swallowing
  • swelling in any part of the body
  • dizziness or light-headedness
  • redness of the skin
  • an itchy rash or itchy skin.
  • pain in the part of your arm where the infusion needle was inserted
  • chills, shivering, or high fever
Other Side Effects: Ustekinumab may weakens the immune system and may make you more prone to get infections. Report to your doctor right away in case you observe any of the following symptoms that may be an indication of infection:
  • fever, flu-like symptoms
  • night sweats
  • feeling tired
  • short of breath
  • a cough that won’t go away
  • superficial fungal infections
  • warm, red, painful skin, or a painful skin rash with blisters
  • burning when passing urine
 Commonly reported side effects that may be responsible for affecting up to 1 in every 10 individuals taking ustekinumab include: 
  • sore throat
  • common cold
  • dizziness
  • headaches
  • diarrhoea
  • nausea or vomiting
  • itching
  • back pain, muscle pain, joint pain
  • fatigue or feeling tired
Less commonly, some individuals recieving ustekinumab may have tooth infections, a blocked nose, bleeding/bruising at injection site, depression, temporary sagging of the muscles on one side of the face, or women may hav vaginal infections.
Although rare, and not reported for individual with Crohn’s, those with psoriasis may have serious skin conditions named erythrodermic psoriasis or exfoliative dermatitis. Report to your health specialist immediately in case you observe an increase in redness or shedding of skin over a wide area.
 
Storage: Keep stelara injection in the fridge between 2°C to 8°C and should not be frozen. If required, this medication can be placed at room temperature, up to 30°C, for up to 30 days in the original box. Once this medication has been stored at the room temperature, it should not be returned to the fridge. Syringes needs to be discarded when they reach the expiry date, or following 30 days if left outside the fridge.
 
Price: The stelara 45 mg price is expected to vary, depending on the innovator  to generic version brands. In order to get the price and procurement details, kindly contact us today at 
TOLL-FREE Number: 1800-889-1064. 
  • Posted by admin
  • On December 9, 2021
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Tags: stelara 130 mg, stelara 45 mg, ustekinumab injection, ustekinumab price

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        • NAVELBINE ORAL (Vinorelbine)
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        • Zepzelca (Lurbinectedin)
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        • Rezurock (Belumosudil)
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        • Xospata (Gilteritinib)
        • Asparlas (Calaspargase pegol-mknl)
        • Polivy (Polatuzumab Vedotin-piiqa
        • Reblozyl (Luspatercept–aamt)
        • Ukoniq (Umbralisib)
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        • Zynlonta (Loncastuximab Tesirine-lpyl)
        • Rylaze
        • Exkivity (Mobocertinib)
        • SCEMBLIX®(Asciminib)
        • Besremi (Ropeginterferon alfa-2b-njft)
        • SARCLISA® (isatuximab-irfc)
        • Inqovi (decitabine and cedazuridine)
        • Blenrep (Belantamab Mafodotin-blmf)
        • Monjuvi (Tafasitamab-cxix)
        • TAFINLAR (Dabrafenib)
        • CALQUENCE (Acalabrutinib)
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        • TREOSULFAN (Treosulfan)
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        • VENCLEXTA (Venetoclax)
        • SOLIRIS (eculizumab)
        • SYNRIBO (Omacetaxine Mepesuccinate)
        • ALKERAN (Melphalan)
        • FARYDAK (Panobinostat)
        • BOSULIF (Bosutinib)
        • ELDISINE (Vindesine Sulphate)
        • Ixazomib Citrate
        • TEPADINA (Thiotepa)
        • ZOLINZA (Vorinostat)
      • Nephrology
        • Ultomiris (Ravulizumab)
      • GASTROENTROLOGY
        • VOSEVI (Sofosbuvir, Velpatasvir, And Voxilaprevir)
        • OLYSIO (SIMEPREVIR)
        • SYPRINE (Trientine HCL)
      • NEUROLOGY
        • Azstarys (Serdexmethylphenidate and Dexmethylphenidate)
        • Qelbree (Viloxazine)
        • Lybalvi (Olanzapine and Samidorphan)
        • Aduhelm (aducanumab-avwa)
        • NUEDEXTA (Dextromethorphan Hydrobromide)
        • ILARIS (Canakinumab)
        • GLIOLAN (Aminolevulinic acid hydrochloride)
        • STELARA (Ustekinumab)
        • HUMIRA (Adalimumab)
      • IMMUNOLOGY
        • Ocrevus (Ocrelizumab)
        • Skyrizi (Risankizumab-rzaa)
        • PONVORY®(ponesimod)
        • Zeposia (Ozanimod)
        • SILIQ (Brodalumab)
        • TREMFYA (Guselkumab)
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        • Nulibry (Fosdenopterin)
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        • Symdeko (Tezacaftor/Ivacaftor & Ivacaftor)
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        • Orfadin (Nitisinone)
        • Trikafta (elexacaftor, tezacaftor and ivacaftor)
        • Spinraza (Nusinersen)
        • Amondys 45 (Casimersen)
        • Voxzogo (Vosoritide)
        • Tepezza (Teprotumumab-trbw)
        • Isturisa (Osilodrostat)
        • Koselugo (Selumetinib)
        • VILTEPSO (Viltolarsen)
        • XERMELO (Telotristat)
        • BRINUERA(Cerliponase alfa)
        • MEPSEVII (Vestronidase)
        • PARSABIV (Etelcalcetide)
        • RADICAVA (Edaravone)
        • RHOPRESSA (Netarsudil)
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        • Vyndaqel (tafamidis meglumine)
      • MISC.
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