Columvi (Glofitamab-gxbm)
- Medicine Name: Columvi
- Generic Name: Glofitamab-gxbm
- Dosage Form & Strength: Injection: 2.5 mg/2.5 mL (1 mg/mL) and 10 mg/10 mL (1 mg/mL) in a single-dose vial
- Manufactured By: Genentech, Inc.
Columvi (glofitamab-gxbm) is a bispecific CD20-directed CD3 T-cell engager used to treat adults with certain types of diffuse large B-cell lymphoma (DLBCL) or large B-cell lymphoma (LBCL) that has returned back (relapsed) or that did not respond to earlier treatment (refractory), and who have received a couple of or more prior therapies for their disease.
Recommended Dosage: The recommended dosage of Columvi injection is administered as a drip into a vein (an intravenous infusion). Patients will be given 12 treatment cycles. Each lasts 21 days. A doctor will begin treatment with a low dose of Columvi and will gradually enhance it to the full dose. A typical schedule is as follows.
- Cycle 1: This will include a pre-treatment with obinutuzumab and 2 low doses of Columvi during the 21 days:
- Day 1 – Pre-treatment with obinutuzumab 1,000 mg intravenously 7 days prior to starting Columvi
- Day 8 – starting low dose of Columvi 2.5 mg
- Day 15 – the second low dose of Columvi 10 mg
- Cycle 2 to Cycle 12: During 2-12 cycles, patients will only be given one dose of Columvi every 21 days:
- Day 1 – full dose of Columvi 30 mg
The first infusion will be given over four hours. A doctor will monitor patients carefully during the first infusion and for 10 hours after the infusion. This is to look out for any signs or symptoms of CRS.
Continue treatment for a maximum of 12 cycles (inclusive of Cycle 1 step-up dosing) or until disease progression or unacceptable toxicity, whichever occurs first.
- Columvi 2.5 mg or 10 mg can cause severe and fatal cytokine release syndrome (CRS). Administer this medicine in a facility equipped to manage and monitor CRS. Start therapy as per the Columvi step-up dosing schedule to minimize the probability of CRS, administer pretreatment medicines, and ensure sufficient hydration.
- Columvi can cause severe and fatal neurologic toxicity, including Immune Effector Cell-Associated Neurotoxicity (ICANS). Evaluate patients for signs and symptoms of neurologic toxicity, monitor, and provide supportive therapy; withhold or permanently discontinue this treatment based on severity.
- Columvi can cause severe or fatal infections. Do not administer it in those patients with an active infection. Antimicrobial prophylaxis needs to be administered as per guidelines. Monitor patients prior to and throughout treatment for infection and treat accordingly.
- Glofitamab 2.5 mg or 10 mg can cause critical tumor flare. Those with bulky tumors or diseases situated in near proximity to airways or a vital organ should be evaluated closely during initial therapy. Assess for signs and symptoms of compression or obstruction because of mass effect secondary to tumor flare, and institute suitable treatment.
- The mechanism of action suggests that Columvi may cause fetal harm if administered to a pregnant woman. Females of reproductive potential should use effective contraception during treatment with Columvi injection and for 30 days after the final dose.
What documents are required to import COLUMVI to India?
COLUMVI (glofitamab-gxbm) injection can be imported by patients or government hospitals on the name of the patients only.
The following documentation is required to import the product:
- A valid prescription from a qualified doctor.
- Patients diagnostic reports
- Patients ID proof (issued by the government of India)
How does the order be confirmed?
The order will be confirmed only after the receipt of:
- A valid prescription from Doctor
- Import permit if applicable
Is COLUMVI available in India?
COLUMVI (glofitamab-gxbm injection) is a (prescription drug, prescription medication, or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.IPN (Indian Pharma Network) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is the facilitator providing input
- On availability of Columvi in India (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Pune etc.)
- Medicine Price.
- Finding Genuine and reliable sources from the USA, Canada, Europe, and Australia
- Ensuring 100% transparency.
COLUMVI can be made available to patients, doctors, and hospitals in Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow, and Pune and other cities in India. The order will be confirmed only after the receipt of a valid prescription from the doctor and an import permit.
IPN (Indian Pharma Network) can facilitate the supply of COLUMVI (prescription medicines) to all locations in the world and in India after fulfilling the legal requirement (if applicable)
Please contact +91-9310090915 | or write us at info@indianpharmanetwork.in for Columvi price in India.
We take to guarantee quality and delivery anywhere in the world as per the buyer’s requirements.
Indian Pharma Network is able to source the COLUMVI (Cancer Treatment Medicines) from across the globe and has the ability to supply. Indian Pharma offers its customers worldwide access to the best available treatment.
Indian Pharma Network (IPN) is able to dispense any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the Patient’s address only from New Delhi, India.
What is the Generic Name for the trade name drug Columvi?
Glofitamab-gxbm is the Generic Name for the trade name drug Columvi.
What is the Manufacturer’s Name of Columvi?
Genentech, Inc manufactures Columvi.
Is Columvi approved by the FDA?
Yes. Columvi is approved by the FDA. Date of first approval: June 15, 2023.
What strengths and dosage forms are available for Columvi?
Columvi is supplied as an injection: 2.5 mg/2.5 mL (1 mg/mL) and 10 mg/10 mL (1 mg/mL) in a single-dose vial for intravenous use.
What are the most common side effects of Columvi?
The most commonly reported side effects of Columvi are cytokine release syndrome, rash, musculoskeletal pain, and fatigue.
What is the availability of Columvi near Medanta Hospital in Gurgaon?
Patients can buy Columvi near Medanta Hospital through a patient-specific import pathway. With a valid oncologist’s prescription, the treatment can be arranged and delivered directly to the hospital in Gurgaon.
What is the availability of Columvi in Bangalore?
Columvi in Bangalore is not yet commercially marketed, but patients can still access it through regulated import provisions. Once prescribed by a treating clinician, the medicine is sourced internationally and supplied to the treating hospital.
Is Columvi available at HCG Cancer Centre, Bangalore?
Columvi may not be routinely stocked in India. However, it can be accessed through a Named Patient Program (NPP) with a valid prescription from an oncologist at the hospital. Indian Pharma Network (IPN) can help facilitate the import of Columvi at HCG Cancer Centre, Bangalore.
What is the availability of Columvi in Mumbai?
Patient can access Columvi in Mumbai via special access programs that allow import of medicines approved in the global market, but unavailable in India. The treatment is delivered to the hospital where the patient is undergoing care.
I want to buy Columvi in Mumbai. How can I access it?
If you are looking to buy Columvi in Mumbai, the first step is consultation with your oncologist. Once prescribed, the medicine can be sourced from global suppliers through a compliant import process and delivered to your treating hospital.
What is the availability of Columvi in Chennai?
Patient access to Columvi in Chennai is possible through special access programs such as Named Patient Programs (NPP), which allow the import of internationally approved medicines. The treatment is arranged and delivered directly to the hospital where the patient is receiving care, ensuring compliance with regulatory requirements.
I want to buy Columvi in Chennai. How can I access it?
If you are looking to access Columvi in Chennai, the first step is to consult your oncologist. Upon prescription, the medicine can be sourced from global suppliers through a compliant import process under NPP and delivered to your treating hospital, such as Apollo Hospitals Chennai or Cancer Institute (WIA).
What is the availability of Columvi in Hyderabad?
Columvi is accessible in Hyderabad through special access programs like Named Patient Programs (NPP), which enable the legal import of medicines not widely available in India. The medication is delivered directly to the hospital where the patient is undergoing treatment.
I want to buy Columvi in Hyderabad. How can I access it?
To buy Columvi in Hyderabad, patients should first consult their oncologist. Once prescribed, the medicine can be arranged through authorized channels under NPP guidelines and delivered to the treating hospital, such as Basavatarakam Indo-American Cancer Hospital.
I want to buy Columvi in Bangalore. How can I access it?
Patients seeking access to Columvi in Bangalore should consult their oncologist for evaluation and prescription. Following this, the medicine can be procured through compliant import channels and delivered to the treating hospital, such as HCG Cancer Centre Bangalore.
Can I buy Columvi at major hospitals like Tata, HCG Cancer Centre, Apollo, or Fortis?
Columvi can be accessed at leading hospitals such as Tata Memorial Centre, HCG Cancer Centre, Basavatarakam Indo-American Cancer Hospital, Cancer Institute (WIA), Apollo Hospitals, Fortis Healthcare, Max Healthcare, Rajiv Gandhi Cancer Institute & Research Centre, Manipal Hospitals, and Kokilaben Dhirubhai Ambani Hospital through the Named Patient Program (NPP) with a valid oncologist’s prescription. Indian Pharma Network assists with import and delivery to the treating hospital.
How does Columvi Import in India work?
Columvi Import in India is possible through the Named Patient Program. This means the medicine can be imported for a specific patient with a valid doctor’s prescription. Indian Pharma Network helps manage the complete process, including approvals and delivery, making sure the medicine reaches the patient safely and legally.
Who is a reliable Columvi supplier in India?
Indian Pharma Network is a trusted Columvi supplier in India, facilitating compliant access through global sourcing channels and structured documentation support for eligible patients under applicable regulatory provisions.
How much does Columvi cost in India?
Columvi is not yet approved in India. However, patients in India can legally access it through the provision called the Named Patient Program (NPP). Columvi prices may fluctuate over time because of market dynamics and regulatory changes. For the most transparent and latest Columvi cost in India, please call/WhatsApp +91 98104 69557 or send an email to info@indianpharmanetwork.in.
Can Columvi be available in SAARC countries?
Apart from Gulf countries, Columvi can be accessed through import provisions like the Named Patient Program (NPP) in SAARC countries (India, Afghanistan, Maldives, Nepal, Bangladesh, Bhutan, Pakistan, and Sri Lanka). Indian Pharma Network (IPN) can help facilitate the legal supply of Columvi in these countries. We help provide legal access to this therapeutic drug through our reliable channels.
Is it safe to buy Columvi online in India?
Yes, one can buy Columvi in India at the lowest price from the Indian Pharma Network (IPN) if this medicinal product is not yet registered or available in their country. We can help facilitate the supply of Columvi through legal channels.
Who is an authorized Columvi importer in India?
Indian Pharma Network acts as the Columvi importer in India, assisting with Named Patient Import processes, regulatory documentation, and compliant international procurement for patients requiring this therapy.
In which countries is Columvi approved?
Columvi has received regulatory approval across several major global markets, including the USA, Canada, China, and the European Union.
Can I buy Columvi from Europe, the USA, or other countries?
Columvi is approved and available in several countries worldwide, including the USA, Canada, China, and the European Union, but patients in India cannot purchase it directly from abroad. It can be legally accessed through the Named Patient Program (NPP) with a valid prescription. Indian Pharma Network assists with compliant sourcing and delivery to the treating hospital.
What are the storage conditions of Columvi?
Store refrigerated at 2°C to 8°C (36°F to 46°F) in original carton to protect from light. Do not freeze. Do not shake.
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