Medical Uses
Datroway (datopotamab deruxtecan-dlnk) is a TROP2-directed antibody-drug conjugate. It links a monoclonal antibody that targets the TROP2 protein on cancer cells to a topoisomerase I inhibitor payload (an exatecan derivative, DXd) via a cleavable linker, delivering the cytotoxic drug more directly to the tumour.
It is approved for adults with:
- HR-positive, HER2-negative breast cancer — unresectable or metastatic hormone receptor-positive, HER2-negative (IHC 0, IHC 1+, or IHC 2+/ISH–) breast cancer, after prior endocrine-based therapy and chemotherapy for unresectable or metastatic disease.
- Triple-negative breast cancer (TNBC) — unresectable or metastatic TNBC in patients who are not candidates for PD-1/PD-L1 inhibitor therapy (a first-line option approved in 2026).
- EGFR-mutated non-small cell lung cancer (NSCLC) — locally advanced or metastatic EGFR-mutated NSCLC after prior EGFR-directed therapy and platinum-based chemotherapy (granted under accelerated approval based on response rate and duration of response).
The relevant receptor or mutation status must be confirmed before treatment. It is a prescription anticancer medicine and must be used under the supervision of a qualified oncologist.
Recommended dosage:
The recommended dose of Datroway is 6 mg/kg given as an intravenous infusion once every 3 weeks (a 21-day cycle), continued until disease progression or unacceptable toxicity. The first infusion is given more slowly with observation; later infusions may be given over a shorter time if well tolerated. Premedication (including anti-nausea medicines and, per the label, medicines to reduce eye and mouth side effects) is given, along with recommended eye care and mouth care. Datroway is given only as an IV infusion. The treating oncologist always determines dosing and any modifications.
