Braftovi (Encorafenib)

Braftovi (encorafenib) is a kinase inhibitor used for the management of certain types of cancer. It is a kinase inhibitor. It works in combination with other medicines for better results. Braftovi is used with binimetinib to treat adults with unresectable or metastatic melanoma that has a BRAF V600E or V600K mutation. It is also used with cetuximab to treat adults with metastatic colorectal cancer (CRC) with a BRAF V600E mutation. Additionally, Braftovi is combined with binimetinib to treat adults with metastatic non-small cell lung cancer (NSCLC) with a BRAF V600E mutation. 

Limitations of Use: Do not use this therapeutic drug for the treatment of patients with wild-type BRAF melanoma, wild-type BRAF CRC, or wild-type BRAF NSCLC.

Recommended Dosage: Confirm the presence of a BRAF V600E or V600K mutation in tumor specimens before starting treatment with Braftovi. 

• Melanoma and Non-Small Cell Lung Cancer (NSCLC): The recommended dosage is 450 mg (six 75 mg capsules) orally once daily together with binimetinib until there is evidence of disease progression or unacceptable toxicity.
• Colorectal Cancer (CRC): The recommended dosage is 300 mg (four 75 mg capsules) orally once daily together with cetuximab until there is evidence of disease progression or unacceptable toxicity. 

Braftovi capsules may be taken with or without food. Do not take a missed dose within 12 hours of the next dose of Braftovi. Do not take any additional dose if vomiting occurs after the administration of this medication but continue with the very next scheduled dose.

• Treatment with Braftovi 75 mg capsules may increase the probability of developing new primary cancers, such as cutaneous squamous cell carcinoma or basal cell carcinoma (BCC). Regular skin examinations are recommended before, during, and after treatment to recognize and manage malignancies appropriately.
• This therapy can increase the growth of tumors in patients with BRAF wild-type tumors. Avoid its use in these situations and confirm BRAF V600E or V600K mutation status through approved diagnostic tests before starting treatment.
• Encorafenib treatment may reduce heart function, which may cause cardiomyopathy. Monitor cardiac function before and during treatment, mainly in patients with heart disease. Let your doctor know if you experience fatigue, shortness of breath, or swelling in your legs.
• Liver problems, including increased liver enzyme levels, can arise with the use of this medication. Regularly monitor liver function tests and let your doctor know if you notice symptoms such as yellowing of the skin or eyes, dark urine, or severe abdominal pain.
• Serious bleeding events, including gastrointestinal and intracranial hemorrhages, have been reported. Patients should be monitored for signs of bleeding, such as unusual bruising or black stools. Notify your doctor immediately if bleeding occurs.
• Eye inflammation, including uveitis, can occur during treatment with Braftovi. Symptoms include eye pain, redness, or vision changes. Regular eye examinations are recommended, and report any eye problems to your healthcare provider promptly.
• Treatment with Braftovi 75 mg oral capsules can harm an unborn baby. Women of childbearing age should use effective contraception during treatment and for at least 2 weeks after the last dose. Men with partners who may become pregnant should also use contraception.
• Patients receiving treatment with this therapeutic drug should avoid breastfeeding during and for at least 2 weeks after the last dose. It is unknown if the drug passes into breast milk, but it could harm a nursing baby.

What documents are required to import BRAFTOVI to India?

 How does order be confirmed?

Indian Pharma Network is able to source the BRAFTOVI (Cancer Treatment Medicines) from across the globe, and has the ability to supply. Indian Pharma Network offers its customers worldwide access to the best available treatment.

Indian Pharma Network is able to dispense any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the Patient’s address only from New Delhi, India.

What is the Generic Name for the trade name drug Braftovi?

Encorafenib is the Generic Name for the trade name drug Braftovi.

What is the Manufacturer’s Name of Braftovi?

Array BioPharma Inc. (Pfizer Inc.) manufactures Braftovi.

Is Braftovi approved by the FDA?

Yes. Braftovi is approved by the FDA. Date of first approval: June 27, 2018.

What strengths and dosage forms are available for Braftovi?

Braftovi is supplied as Capsules: 75 mg for oral administration.

What are the most common side effects of Braftovi? 

The most commonly reported side effects of Braftovi are:

• Melanoma (in combination with binimetinib): fatigue, nausea, vomiting, abdominal pain, and arthralgia 
• CRC (in combination with cetuximab and mFOLFOX6): peripheral neuropathy, rash, nausea, fatigue, decreased appetite, diarrhea, vomiting, hemorrhage, pyrexia, abdominal pain, arthralgia, and constipation.
• in combination with cetuximab and FOLFIRI: nausea, diarrhea, abdominal pain, fatigue, vomiting, alopecia, constipation, decreased appetite, and rash 
• in combination with cetuximab: fatigue, nausea, acneiform dermatitis, diarrhea, abdominal pain, arthralgia, decreased appetite, and rash. 
• NSCLC (combination with binimetinib): fatigue, nausea, musculoskeletal pain, vomiting, diarrhea, abdominal pain, visual impairment, rash, constipation, dyspnea, and cough. 

What is the availability of Braftovi near Medanta Hospital in Gurgaon?

Patients can buy Braftovi near Medanta Hospital through a patient-specific import pathway. With a valid oncologist’s prescription, the treatment can be arranged and delivered directly to the hospital in Gurgaon.

What is the availability of Braftovi in Bangalore?

Braftovi in Bangalore is not yet commercially marketed, but patients can still access it through regulated import provisions. Once prescribed by a treating clinician, the medicine is sourced internationally and supplied to the treating hospital.

Is Braftovi available at HCG Cancer Centre, Bangalore?

Braftovi may not be routinely stocked in India. However, it can be accessed through a Named Patient Program (NPP) with a valid prescription from an oncologist at the hospital. Indian Pharma Network (IPN) can help facilitate the import of Braftovi at HCG Cancer Centre, Bangalore.

What is the availability of Braftovi in Mumbai?

Patient can access Braftovi in Mumbai via special access programs that allow import of medicines approved in the global market, but unavailable in India. The treatment is delivered to the hospital where the patient is undergoing care.

I want to buy Braftovi in Mumbai. How can I access it?

If you are looking to buy Braftovi in Mumbai, the first step is consultation with your oncologist. Once prescribed, the medicine can be sourced from global suppliers through a compliant import process and delivered to your treating hospital.

What is the availability of Braftovi in Chennai?

Patient access to Braftovi in Chennai is possible through special access programs such as Named Patient Programs (NPP), which allow the import of internationally approved medicines. The treatment is arranged and delivered directly to the hospital where the patient is receiving care, ensuring compliance with regulatory requirements.

I want to buy Braftovi in Chennai. How can I access it?

If you are looking to buy Braftovi in Chennai, the first step is to consult your oncologist. Upon prescription, the medicine can be sourced from global suppliers through a compliant import process under NPP and delivered to your treating hospital, such as Apollo Hospitals or Cancer Institute (WIA).

What is the availability of Braftovi in Hyderabad?

Braftovi in Hyderabad is accessible through special access programs like Named Patient Programs (NPP), which enable the legal import of medicines not widely available in India. The medication is delivered directly to the hospital where the patient is undergoing treatment.

I want to buy Braftovi in Hyderabad. How can I access it?

To buy Braftovi in Hyderabad, patients should first consult their oncologist. Once prescribed, the medicine can be arranged through authorized channels under NPP guidelines and delivered to the treating hospital, such as Basavatarakam Indo-American Cancer Hospital.

I want to buy Braftovi in Bangalore. How can I access it?

Patients seeking access to Braftovi in Bangalore should consult their oncologist for evaluation and prescription. Following this, the medicine can be procured through compliant import channels and delivered to the treating hospital, such as HCG Cancer Centre Bangalore.

Can I buy Braftovi at major hospitals like Tata, HCG Cancer Centre, Apollo, or Fortis?

Braftovi can be accessed at leading hospitals such as Tata Memorial Centre, HCG Cancer Centre, Basavatarakam Indo-American Cancer Hospital, Cancer Institute (WIA), Apollo Hospitals, Fortis Healthcare, Max Healthcare, Rajiv Gandhi Cancer Institute & Research Centre, Manipal Hospitals, and Kokilaben Dhirubhai Ambani Hospital through the Named Patient Program (NPP) with a valid oncologist’s prescription. Indian Pharma Network assists with import and delivery to the treating hospital.

How does Braftovi Import in India work?

Braftovi Import in India is possible through the Named Patient Program. This means the medicine can be imported for a specific patient with a valid doctor’s prescription. Indian Pharma Network helps manage the complete process, including approvals and delivery, making sure the medicine reaches the patient safely and legally.

Who is a reliable Braftovi supplier in India?

Indian Pharma Network is a trusted Braftovi supplier in India, facilitating compliant access through global sourcing channels and structured documentation support for eligible patients under applicable regulatory provisions.

How much does Braftovi cost in India?

Braftovi is not yet approved in India. However, patients in India can legally access it through the Named Patient Program (NPP). Braftovi prices may fluctuate over time because of market dynamics and regulatory changes. For the most transparent and latest Braftovi cost in India, please call: +91 96548 60915, WhatsApp +91 98104 69557, or send an email to info@indianpharmanetwork.in.

Can Braftovi be available in SAARC countries? 

Apart from Gulf countries, Braftovi can be accessed through import provisions like the Named Patient Program (NPP) in SAARC countries (India, Afghanistan, Maldives, Nepal, Bangladesh, Bhutan, Pakistan, and Sri Lanka). Indian Pharma Network (IPN) can help facilitate the legal supply of Braftovi in these countries. We help provide legal access to this therapeutic drug through our reliable channels.

Is it safe to buy Braftovi online in India?

Yes, one can buy Braftovi in India at the lowest price from the Indian Pharma Network (IPN) if this medicinal product is not yet registered or available in their country. We can help facilitate the supply of Braftovi through legal channels. 

Who is an authorized Braftovi importer in India?

Indian Pharma Network acts as the Braftovi importer in India, assisting with Named Patient Import processes, regulatory documentation, and compliant international procurement for patients requiring this therapy.

In which countries is Braftovi approved?

Braftovi has received regulatory approval across several major global markets, including the USA, Canada, Japan, China, and throughout the European Union.

Can I buy Braftovi from Europe, the USA, or other countries?

Braftovi is approved and available in several countries worldwide, including the USA, Canada, Japan, China, and throughout the European Union, but patients in India cannot purchase it directly from abroad. It can be legally accessed through the Named Patient Program (NPP) with a valid prescription. Indian Pharma Network (IPN) assists with compliant sourcing and delivery to the treating hospital.

What are the storage conditions of Braftovi?

Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F). Dispense in the original bottle. Do not remove desiccant. Protect from moisture. Keep the container well closed.