Stomach Gastric Cancer and Targeted Drug Therapy
Key Highlights:
- The stomach is a significant part of the human digestive system, which takes in and breaks down food, absorbs nutrients, and eliminates waste from the body.
- Most stomach/stomach cancers begin in cells that line the inside of the stomach wall and secrete mucus. These stomach cancers are named adenocarcinomas.
- The stomach wall consists of 5 significant layers: mucosa, submucosa, muscle, subserosa, and serosa. Cancer starts in the innermost layer and progresses outward through the layers of the stomach wall.
- Gastric cancers tend to occur slowly over many years. Before cancer develops, pre-cancerous changes often appear in the mucosa (inner lining) of the stomach.
- Early-stage gastric/stomach cancer has not progressed beyond the mucosa (first layer) of the stomach wall. The tumor is often tiny and is not in any lymph nodes.
- In locoregional or locally advanced stomach cancer, cancer has invaded the submucosa (second layer) of the stomach/gastric or beyond. Cancer might be detected in regional or nearby lymph nodes.
- Cancer can progress to distant parts of the body through the lymphatic system or blood. This is known as metastatic stomach cancer. A distant metastasis could be in the abdominal lining, liver, or distant lymph nodes.
Targeted Drug Therapy for Stomach Cancer
As health specialists have researched more about the changes in cells that are responsible for causing cancer, they have discovered newer medicines that mainly target these changes. The targeted drugs are designed to work differently from standard chemo medicines. They sometimes work well when standard chemo medicines don’t, and they often have different adverse reactions.
Targeted drug therapy can sometimes be used for the treatment of stomach/gastric cancer, either alone or together with chemotherapy, on behalf of the situation.
Drugs Designed to Target HER2: In some individuals with stomach or gastric cancer, the unhealthy cells have excess growth-promoting protein named HER2 on their surface. Cancers with high HER2 are known as HER2-positive. Drugs that are designed to target HER2 protein can often be effective in treating these cancers.
Trastuzumab (Herceptin, others): Trastuzumab is a monoclonal antibody, a human-made version of an immune system protein, which is designed to target HER2. the addition of trastuzumab to chemotherapy can help individuals with advanced, HER2 +Ve stomach cancer live longer than just chemotherapy alone.
This medicinal product only acts if the unhealthy cells have excess HER2, so samples of cancer must be tested for HER2 prior to initiating treatment.
Trastuzumab is infused through an IV line or central venous catheter into the vein. For stomach cancer, the medicine is typically given once every 2 or 3 weeks together with chemotherapy.
Adverse Reactions: The commonly reported adverse reactions of trastuzumab tend to be relatively mild. Adverse reactions can include fever, nausea, weakness, vomiting, headache, diarrhea, and cough. These reactions occur less often after the first dose.
Fam-trastuzumab deruxtecan (Enhertu): Enhertu is supplied for injection: 100 mg lyophilized powder in a single-dose vial. It is an antibody-drug conjugate, which is specifically a monoclonal antibody linked to chemotherapy medication. In this scenario, the anti-HER2 antibody acts like a homing signal by attaching to the HER2 protein on unhealthy cells, bringing the chemotherapy directly to them.
Enhertu injection can be used by itself for the treatment of advanced HER2 +Ve stomach cancer, usually, after treatment with trastuzumab has been tried.
This medicinal product is infused through an IV line or central venous catheter into the vein. For stomach or gastric cancer, it is usually given once every three weeks.
Adverse Reactions: This medicine can cause low blood cell counts, which can increase an individual`s risk of infections and bleeding. Other common adverse reactions of this medicine can include vomiting, fever, loss of appetite, nausea, diarrhea, hair loss, and feeling tired.
Where Do I Get Enhertu and Other Medicines for Stomach Cancer :
Enhertu 100 mg can be made available from India. The medicine can also be known as Fam-trastuzumab deruxtecan. It is supplied as an injection: 100 mg lyophilized powder in a single-dose vial. Kindly get in touch with us via TOLL-FREE: 1800-889-1064 to buy Enhertu injection at genuine price. We are a WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporter/ Importer from India of Enhertu 100 mg lyophilized powder in a single-dose vial.
Note: There are certain other medicines approved for the treatment of Stomach/Gastric cancer:
Ramucirumab (Cyramza): This medicine is designed to target VEGF.
Larotrectinib (Vitrakvi) and entrectinib (Rozlytrek): These medicines target the TRK proteins.
Reference:
https://www.healthline.com/health/gastric-cancer
- Posted by admin
- On February 15, 2023
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