Orfadin (Nitisinone)

Orfadin (nitisinone) is a hydroxy-phenylpyruvate dioxygenase inhibitor used to treat hereditary tyrosinemia type 1 (HT-1) in both adults and children. This medication works by blocking the enzyme that causes a buildup of harmful substances in the body. Orfadin is typically prescribed alongside a special diet that restricts the intake of tyrosine and phenylalanine, essential amino acids, to manage the condition effectively. By reducing the levels of toxic substances, Orfadin helps prevent liver and kidney damage associated with HT-1, improving the quality of life for patients with this rare genetic disorder.

Recommended Dosage:

• Starting Dosage: The recommended starting dosage of Orfadin is 0.5 mg/kg, administered orally twice a day.
  
• Maintenance Regimen: For patients aged 5 years and older who achieve undetectable levels of serum and urine succinylacetone after at least 4 weeks on a stable nitisinone dosage, the total daily dose of Orfadin may be administered once daily (e.g., 1 to 2 mg/kg once a day).
  

• Nitisinone can cause elevated plasma tyrosine levels, leading to ocular symptoms such as keratitis, photophobia, and corneal ulceration. Regular monitoring of plasma tyrosine levels is necessary, and dietary restrictions on tyrosine and phenylalanine intake are recommended to mitigate these effects.
  
• Patients may experience eye-related complications, such as visual discomfort and blurred vision. It is important to monitor for any signs of keratopathy or other ocular disturbances, and immediate ophthalmologic assessment is recommended if symptoms occur.
  
• Patients, particularly children, may present with developmental delays and hyperkeratotic plaques. Growth and neurological development should be closely monitored during treatment.
  
• Treatment with Orfadin 2 mg, 5 mg, 10 mg, or 20 mg may cause leukopenia and severe thrombocytopenia, potentially leading to infection and bleeding risks. Regular blood counts should be conducted to identify these conditions early.
  
• This therapeutic drug should only be used during pregnancy if the potential benefits outweigh the risks. Breastfeeding is not recommended while on Orfadin, as it may pass into breast milk and harm the infant.
  
• Concomitant use of Orfadin with other medications should be approached with caution due to potential drug interactions. Consult a healthcare professional before combining treatments.
  

What documents are required to import ORFADIN to India?

ORFADIN (nitisinone) capsules can be imported by patients or government hospitals on the name of the patients only. 

The following documentation is required to import the product:

• A valid prescription from a qualified doctor.
  
• Patients diagnostic reports
  
• Patient ID proof (issued by the government of India)

The order will be confirmed only after the receipt of:

• Valid prescription of Doctor
  
• Import permit if applicable

ORFADIN (nitisinone capsules) is a (prescription drug, prescription medication, or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.

IPN (Indian Pharma Network) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is the facilitator providing input:

• On availability of Orfadin in India (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Pune etc.)
  
• On availability in Gulf countries (Bahrain, Oman, Qatar, Kuwait, Iraq, Saudi Arabia, and the UAE).
  
• Medicine Price.
  
• Finding Genuine and reliable sources from Canada, Europe, the USA, and Australia
  
• Ensuring 100% transparency.

IPN (Indian Pharma Network) can facilitate the supply of ORFADIN (prescription medicines) to all locations in the world and India after fulfilling the legal requirement (if applicable).

Please contact +91 9310090915 | Toll-Free No: 1800-889-1064 or write us at info@indianpharmanetwork.in for Orfadin capsule price in India. 

We guarantee quality and delivery anywhere in the world as per the buyer’s requirements.

Indian Pharma Network (IPN) can source ORFADIN (a cancer treatment medication) from across the globe and supply it to India and other countries where the medicine is not yet approved or unavailable. Through our services, we ensure that patients have worldwide access to the best available treatments.

IPN is capable of dispensing any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the patient’s address directly from New Delhi, India.

Indian Pharma Network helps to connect the patients with potential distributors, wholesalers, suppliers and dealers of Orfadin in India. 

What is the Generic Name for the trade name drug Orfadin®?

Nitisinone is the Generic Name for the trade name drug Orfadin®.

What is the Manufacturer’s Name of Orfadin®?

Orfadin® is manufactured by Swedish Orphan Biovitrum.

Is Orfadin® approved by the FDA?

Yes, Orfadin® is approved by the FDA. Date of first approval: January 18, 2002.

What is the dosage and form of Orfadin® supplied?

Orfadin® is supplied as Capsules: 2 mg, 5 mg, 10 mg, 20 mg for oral administration.

What are the most common side effects of Orfadin®? 

The most common side effects of Orfadin® are thrombocytopenia, elevated tyrosine levels, leukopenia, eye pain, conjunctivitis, corneal opacity, keratitis, photophobia, blepharitis, cataracts, granulocytopenia, dry skin, epistaxis, pruritus, exfoliative dermatitis, maculopapular rash, and alopecia

Where can I Access Orfadin® (Nitisinone) at the best price in India?

Indian Pharma Network (IPN), a certified pharmaceutical facilitator/supplier/importer and WHO-GDP certified offers Orfadin (nitisinone) in India. Although FDA-approved Nitisinone (brand name Orfadin) is not yet registered in India, Indian patients can purchase it upon request at the lowest price. To confirm an order for Orfadin, a valid doctor’s prescription and, if required, an import permit must be submitted.

How much does Orfadin® (Nitisinone) cost in India?

Prices may fluctuate over time due to market dynamics and regulatory changes. To obtain accurate and up-to-date information on nitisinone cost in India, it is recommended to Call/WhatsApp +91-9310090915 or send mail to info@indianpharmanetwork.in.

Can Orfadin® (Nitisinone) be made available in SAARC countries? 

Apart from Gulf countries, Orfadin® can be available in SAARC countries (Afghanistan, India, Bangladesh, Bhutan, Maldives, Nepal, Pakistan, and Sri Lanka). Indian Pharma Network (IPN) can help facilitate the supply of Orfadin® (nitisinone 2 mg, 5 mg, 10 mg, 20 mg capsules) in these countries, ensuring access to this therapeutic drug through legal and reliable channels.

Is it safe to buy Orfadin® (Nitisinone) online in India?

Yes, one can buy Orfadin online in India at the best price from the Indian Pharma Network (IPN) if this medicinal product is not registered or is unavailable in their country. We can help facilitate the supply of Orfadin® capsules through legal channels. 

What are the storage conditions of Orfadin®?

Keep refrigerated between 2° to 8°C (36° to 46°F). Alternatively, Orfadin capsules can be stored at room temperature up to 25°C (77°F) for a maximum of 45 days. If not used within this period, discard the capsules.

In India, where has the Indian Pharma Network (IPN) imported and delivered anti-cancer medicines, including FDA-approved Nitisinone (brand name Orfadin)? 

For personal use, FDA-approved Nitisinone (brand name Orfadin) can be accessed in India through our services. We have successfully imported and delivered anti-cancer medicines to these cities: Bangalore, Ahmedabad, Surat, Kolkata, Pune, Indore, Nagpur, Agra, Kanpur, Patna, Coimbatore, Kochi,, Gurugram, Delhi Amaravati, Itanagar, Dispur, Raipur, Panaji, Gandhinagar, Chandigarh, Shimla, Ranchi, Bengaluru, Thiruvananthapuram, Bhopal, Mumbai, Imphal, Shillong, Aizawl, Kohima, Bhubaneswar, Jaipur, Gangtok, Chennai, Hyderabad, Agartala, Lucknow, Dehradun, Gairsain, Aurangabad, Barshi, Cachar, Dibrugarh, Kollam, Meghalaya, Mizoram, Sikkim, Puducherry, Punjab, Tripura, New Delhi, Alwar, Mathura, Panipat, Faridabad, Noida, Sonipat, Rohtak, Karnal, Ambala, Ghaziabad, etc.

FAQs for Generic Brand Lasinone (Nitisinone 2 MG, 5 MG, 10 MG)

What is Lasinone (Nitisinone 2 mg, 5 mg, 10 mg)?

Lasinone is an Indian generic brand that serves as an alternative to the brand-name medicine Orfadin. It contains the active ingredient Nitisinone, which is used for the treatment of hereditary tyrosinemia type 1 (HT-1).

Is Lasinone (Nitisinone 2 mg, 5 mg, 10 mg) available for export from India?

Yes, we are a leading exporter of Nitisinone-Lasinone (generic Orfadin) from India to various regions worldwide, including Asia, Australia, North America, South America, Central America, Eastern Europe, Western Europe, the Middle East, and Africa.

How can healthcare providers or patients access Lasinone (Nitisinone 2 mg, 5 mg, 10 mg) from India?

To buy Nitisinone 2 mg, 5 mg, 10 mg from India, healthcare providers or patients must provide a valid prescription and comply with the import regulations of the destination country. Indian Pharma Network (IPN) assists in navigating these requirements to ensure smooth delivery.

Where can I get Lasinone (Nitisinone 2 mg, 5 mg, 10 mg) at the best Price? 

Order generic Nitisinone at the best price today. We request that you Call/WhatsApp us at +91-9310090915, dial our TOLL-FREE Number: 1800-889-1064, or write to us at info@indianpharmanetwork.in. We are fully committed to providing you with the best Nitisinone 2 mg, 5 mg, 10 mg price from India. That is why we’ll match the cost/price of any other facilitators/suppliers/distributors in the market who require a valid medical prescription.

Is the Lasinone (Nitisinone 2 mg, 5 mg, 10 mg) available in India?

Lasinone (nitisinone) is a generic alternative to Orfadin and is available in India. It is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription. A generic version of Orfadin can be made available across the world through India’s authorized distributor network. (Ahmedabad, Mumbai, Pune, Kolkata, Hyderabad, Bangalore, Chennai, Delhi, etc.). 

Can You Send the Lasinone (Nitisinone 2 mg, 5 mg, 10 mg) to Foreign Destinations?

Buy generic Nitisinone online at the lowest price from a leading supplier/exporter. We can assist in the delivery of Nitisinone capsules; the doctor-prescribed medication to France, Austria, Belgium, Germany, Ireland, Netherlands, Switzerland, Luxembourg, the UK, Israel, Iraq, Jordan, Bahrain, Egypt, Iran, Kuwait, Qatar, Lebanon, Turkey, UAE, Oman, Saudi Arabia, Syria, Belize, Costa Rica, El Salvador, Guatemala, Italy, Czech Republic, Panama, Russia, Bulgaria, Serbia, Slovakia, Slovenia, Ukraine, Croatia, Estonia, Hungary, Kosovo, Latvia, Lithuania, Moldova, Poland, Romania, Belarus, Argentina, Brazil, Chile, Guyana, Colombia, Peru, Suriname, Ecuador, Paraguay, Uruguay, Venezuela, Canada, Mexico, US, Japan, Sri Lanka, Singapore, Indonesia, and China.

What is the procedure for buying Lasinone (Nitisinone 2 mg, 5 mg, 10 mg) from India? 

Patients can simply fill out the order form or send mail to info@indianpharmanetwork.in. Patients can also send WhatsApp messages to +91-9310090915 or dial the TOLL-FREE Number: 18008891064. We will reply ASAP with the details of the Nitisinone 2 mg/5 mg/10 mg price and the procurement procedure.

Note:- The order will be confirmed only after the valid receipt of the prescription from the Physician.

Is it safe to buy Lasinone (Nitisinone) capsules online from India?

Yes, one can buy Nitisinone online from India-based Indian Pharma Network (IPN)  if the medicinal product is not (yet) registered or is unavailable in their respective country. We can help facilitate the supply of generic Nitisinone through legal channels. 

What are the main export markets for Lasinone (Nitisinone 2 mg, 5 mg, 10 mg)? 

The main export markets for Lasinone (Nitisinone 2 mg, 5 mg, 10 mg capsules) are Western Europe (Germany, Austria, Belgium, France, Ireland, Liechtenstein, Luxembourg, Monaco, United Kingdom, Netherlands, Switzerland, Andorra), Australia, the Middle East (Bahrain, Cyprus, Egypt, Iran, Iraq, Israel, Jordan, Kuwait, Lebanon, Oman, Qatar, Saudi Arabia, Syria, Turkey, UAE, Yemen), Central America (Belize, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama), Eastern Europe (Serbia, Slovakia, Slovenia, Ukraine, Russia, Bulgaria, Croatia, Czech Republic, Estonia, Hungary, Kosovo, Latvia, Lithuania, Moldova, Montenegro, North Macedonia, Poland, Romania, Albania, Belarus, Bosnia, Herzegovina), South America (Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Guyana, Paraguay, Peru, Suriname, Uruguay, Venezuela), Asia (Vietnam, Thailand, Singapore, Sri Lanka, Philippines, Maldives, Malaysia, Japan, Indonesia, China, Bangladesh, Bhutan, Afghanistan), North America (Canada, Mexico, US, Cuba, Jamaica, Haiti, and Africa.