Medical Uses
Itovebi (inavolisib) is a kinase inhibitor used along with palbociclib and fulvestrant to treat adults who have HR-positive, HER2-negative breast cancer that has an abnormal PIK3CA gene, and has progressed to nearby tissue or lymph nodes (locally advanced), or other parts of the body (metastatic), and has returned after hormone (endocrine) therapy.
Recommended Dosage: The recommended dosage is 9 mg taken orally once daily, with or without food, until there is evidence of disease progression or unacceptable toxicity. Take tablets at approximately the same time each day. Swallow tablet(s) whole without chewing, crushing, or splitting.
If a dose is missed, take it as soon as possible within 9 hours. After more than 9 hours, skip the dose and take the very next dose at the scheduled time. If a dose is puked, do not take an additional dose on that day and resume the usual dosing schedule the very next day.
Use Inavolisib in combination with palbociclib and fulvestrant. The recommended dosage of palbociclib is 125 mg orally once daily for 21 successive days followed by 7 days without treatment to make a cycle of 28 days. For premenopausal and perimenopausal women, administer LHRH agonist as per the local clinical practice. For men, consider the use of LHRH agonists as per local clinical practice.