Agilus (Dantrolene Sodium)

Agilus (dantrolene sodium) is a direct-acting muscle relaxant. It is used for the treatment of malignant hyperthermia (rapid rise in body temperature caused by uncontrolled muscle contractions) in adults and children. It is used in combination with supportive measures to manage this rare but life-threatening condition.

Recommended Dosage:
The recommended initial dose of Agilus (dantrolene sodium) for adult and paediatric patients is 2.5 mg/kg body weight administered rapidly by intravenous (IV) injection. Start treatment with Agilus as soon as a malignant hyperthermia crisis is suspected, i.e., characteristically presenting with muscle rigidity, metabolic acidosis, and/or rapidly increasing body temperature.

As long as the main clinical signs and symptoms of hypoventilation, tachycardia, sustained hyperacidity (pH and partial pressure of carbon dioxide (pCO2) monitoring required), and hyperthermia persist, repeat a bolus injection of 2.5 mg/kg every 10 minutes until physiological and metabolic abnormalities improve. In case a cumulative dose of 10 mg/kg or greater is considered, the diagnosis of malignant hyperthermia should be re-examined.

• Dantrolene sodium hemiheptahydrate is used for the management of malignant hyperthermic crisis, but this medicine is not a replacement for any other necessary treatments. These supportive measures can be continued as needed. Use this therapeutic drug alongside these treatments to effectively manage the condition.
• In occurrence of symptoms of hyperkalaemia (like abnormal heart rhythms, muscle weakness), or if you have conditions like kidney complications or digitalis poisoning, be cautious. Animal studies suggest that the use of Agilus with verapamil may lead to an increase in potassium, which can be harmful.
• Use of dantrolene sodium 120 mg injection together with calcium channel blockers is not recommended, as it may cause harmful effects. These medicines can interfere with each other and may increase the probability of complications. Always consult a healthcare provider (HCP) before combining it with other medicines like calcium blockers.
• Dantrolene sodium is intended for intravenous (IV) use only. Because of the solution's high pH (9.5), it can be responsible for causing tissue damage if injected outside the vein. This may lead to serious complications such as tissue death. Do not inject in arteries and any other areas.
• Do not allow the Agilus 120 mg solution to spill on your skin. In case it spills on the skin, immediately wash the affected area with plenty of water to prevent irritation or any potential damage. Make sure the medicine does not come in contact with any part of your body.
• Long-term use of this therapeutic drug can cause liver damage, which may worsen over time. Life-threatening liver injury may establish, sometimes leading to critical conditions. Monitor liver health on regular basis when using this treatment, especially for extended periods or in high doses.
• In case you have kidney problems, the use of dantrolene sodium might increase exposure to hydroxypropylbetadex, a component of the solution. This can increase the risk of adverse reactions, making it important for individuals with renal impairment to use this medicine with extra caution and proper medical supervision.
• Treatment with Agilus 120 mg injection may affect pregnancy, fertility, or breastfeeding, although specific data is not fully clear. It's important to consult with a healthcare provider (HCP) if you're pregnant, want to become pregnant, or breastfeeding before using this medicine to understand any potential risks.
• Dantrolene sodium can cause side effects such as dizziness or tiredness. This may affect your ability to drive or use machines safely. Do not drive or perform activities that require intense focus and alertness if you experience any symptoms like dizziness or drowsiness after using this drug.

What documents are required to import AGILUS to India?

AGILUS (dantrolene sodium hemiheptahydrate) injections can be imported by patients or government hospitals in the name of the patients only.

The following documentation is required to import the product:

• A valid prescription from a qualified doctor.
• Patients diagnostic reports
• Patient ID proof (issued by the government of India)

How does the order get confirmed?

The order will be confirmed only after the receipt of:

• A valid prescription from the Doctor
• Import permit if applicable

Is AGILUS available in India?

AGILUS (dantrolene sodium hemiheptahydrate injections) is a (prescription drug, prescription medication, or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.

IPN (Indian Pharma Network) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is the facilitator, providing input

• On availability of Agilus 120 mg in India (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Pune, etc.)
• On availability in Gulf countries (Bahrain, Oman, Qatar, Kuwait, Iraq, Saudi Arabia, and the UAE).
• Medicine Price.
• Finding Genuine and reliable sources from the USA, Canada, Europe, and Australia
• Ensuring 100% transparency.

AGILUS can be made available to patients, doctors, and hospitals in Mumbai, Goa, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow, and Pune, and other cities in India. The order will be confirmed only after the receipt of a valid prescription from the doctor and an import permit.

IPN (Indian Pharma Network) can facilitate the supply of AGILUS (prescription medicines) to all locations in the world and India after fulfilling the legal requirements (if applicable).

Please contact +91-9310090915 | Toll-Free Number: 1800-889-1064 or write us at info@indianpharmanetwork.in for Agilus 120 mg injection price in India.

We guarantee quality and delivery anywhere in the world as per the buyer’s requirements.

Indian Pharma Network can source AGILUS (Cancer Treatment Medicines) from across the globe and can supply. Indian Pharma offers its customers worldwide access to the best available treatment.

Indian Pharma Network (IPN) can dispense any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the Patient's address only from New Delhi, India.

What is the Generic Name for the trade name drug Agilus®?

Dantrolene sodium hemiheptahydrate is the Generic Name for the trade name drug Agilus®.

What is the Manufacturer's Name of Agilus®?

Agilus® is manufactured by Norgine Limited.

What is the dosage and form of Agilus® supplied?

Agilus® is supplied in 120 mg powder for solution for injection for intravenous (IV) use. Each vial contains 120 mg dantrolene sodium hemiheptahydrate.

What are the most common side effects of Agilus® 120 mg injections?

The most common side effects of Agilus® injection are allergic reactions, hyperkalaemia, rapid heartbeat, difficulty breathing, abdominal pain, nausea, vomiting, diarrhoea, difficulty swallowing, muscle weakness, tired muscles, fatigue, general weakness (asthenia), and reactions at the injection site.

How much does Agilus® 120 mg injection cost in India?

Prices of Agilus injections may fluctuate over time because of market dynamics and regulatory changes. For the most transparent and latest Agilus 120 mg injection cost in India, please Call/WhatsApp +91-9310090915 or send mail to info@indianpharmanetwork.in.

Can Agilus® 120 mg injections be available in SAARC countries?

Apart from Gulf countries, Agilus® can be available in SAARC countries (India, Afghanistan, Maldives, Nepal, Bangladesh, Bhutan, Pakistan, and Sri Lanka). Indian Pharma Network (IPN) can help facilitate the legal supply of Agilus® injections in these countries. We help ensure legal access to this therapeutic drug through our reliable channels.

Is it safe to buy Agilus® 120 mg injections online in India?

Yes, one can buy Agilus 120 mg online in India and other countries at the lowest price from the Indian Pharma Network (IPN) if this medicinal product is not (yet) registered or available in their country. We can help facilitate the legal supply of Agilus® injections through legal channels.

What are the storage conditions of Agilus® 120 mg injections?

The unopened vial of Agilus does not require any specific temperature storage conditions. Keep the vial in the outer carton to protect from light. Protect the reconstituted solution from light. Do not store above 25 °C and do not refrigerate.