Antibody Drug Conjugate (ADC) for TNBC

Triple-negative breast cancer (TNBC) accounts for approximately 10 to 15 percent of all breast cancers. In triple-negative breast cancer (TNBC), the unhealthy cells typically don’t have estrogen or progesterone receptors (ER or PR) and they create very little or none of the human epidermal growth factor receptor 2 (HER2) protein.

Antibody-drug conjugate (ADC): An antibody-drug conjugate (ADC) is a monoclonal antibody joined to a chemotherapy drug. There is a promising antibody-drug conjugate known as trodelvy injection to treat triple-negative breast cancer (TNBC).

Trodelvy (Sacituzumab govitecan): In the case of this antibody-drug conjugate, the monoclonal antibody part attaches to the Trop-2 protein on the cells of breast cancer and brings a chemotherapy medication, identical to irinotecan, directly to them. (Some breast cancer cells have excess Trop-2, which helps them grow and progress rapidly).

Trodelvy is supplied for injection: 180 mg lyophilized powder in single-dose vials for reconstitution. This ADC (trodelvy 180 mg injection) can be used by itself for the treatment of advanced triple-negative breast cancer after at least a couple of other chemotherapy regimens have been used. Dosage of this medicinal product is administered in a vein (IV) weekly for 14 days (2 weeks), followed by 7 days (one week) off, then restarted.

Some commonly reported side effects of trodelvy injection 180 mg include vomiting, nausea, diarrhea, feeling tired, constipation, rash, loss of appetite, low red blood cell counts, hair loss, and belly pain. Very low WBC counts and serious diarrhea can also occur, as reactions when the medicine is infused. Drugs to scale down the probability of an allergic reaction are generally given prior to starting treatment with this medicine.

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