Medical Uses
Sunosi (solriamfetol) is a dopamine and norepinephrine reuptake inhibitor (DNRI) used to improve wakefulness in adult patients with excessive daytime sleepiness (EDS) associated with narcolepsy or obstructive sleep apnea (OSA).
Limitations of Use:
This therapeutic drug does not treat airway blockage in OSA (Obstructive Sleep Apnea). Make sure to treat the airway obstruction first, like using CPAP, for at least 30 days before starting this medicine for daytime sleepiness. Continue using CPAP or other treatments while using Solriamfetol. This medicine is not a replacement for these treatments.
Recommended Dosage: The recommended dosage of Sunosiis administered orally upon awakening with or without food. Avoid taking dosage within 9 hours of planned bedtime because of the risk of interfering with sleep if taken too late in the day.
- Dosage in Narcolepsy: Start treatment at 75 mg once daily in adults with narcolepsy. The recommended dose range is 75 mg to 150 mg once daily. On behalf of the efficacy and tolerability, the dosage may be doubled at intervals of at least 3 days. The maximum recommended dose is 150 mg once daily. Dosages beyond 150 mg daily do not confer increased effectiveness sufficient to outweigh dose-related side effects.
- Dosage in OSA: In adults with OSA, start treatment at 37.5 mg once daily. The recommended dosage range is 37.5 mg to 150 mg once daily. For efficacy and tolerability, the dosage may be doubled at intervals of at least 3 days. The maximum recommended dosage is 150 mg once daily. Dosages beyond 150 mg daily do not confer increased effectiveness sufficient to outweigh dose-related side effects.