Medical Uses
Sensipar/Mimpara (cinacalcet) is a positive modulator of the calcium-sensing receptor indicated for:
- Secondary Hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on dialysis.
- Hypercalcemia in adult patients with Parathyroid Carcinoma (PC)
- Hypercalcemia in adult patients with primary HPT for whom parathyroidectomy would be indicated based on serum calcium levels, but who are unable to undergo parathyroidectomy.
Limitations of Use: This therapeutic drug is not indicated for use in patients with CKD who are not on dialysis.
Recommended Dosage: The recommended dosage of Cinacalcet needs to be taken with food or right after a meal. Prescribed oral tablets should be taken whole, with water, and not chewed, crushed, or broken out in pieces.
Secondary Hyperparathyroidism in Patients with Chronic Kidney Disease on Dialysis: The recommended starting oral dose of Cinacalcet is 30 mg once daily. Within a week, checking serum calcium and serum phosphorus levels is necessary and, within 1 iPTH hormones can be measured 1 to 4 weeks after the initiation or the dose adjustment of Cinacalcet. Titration is to be done no more frequently than every 2-4 weeks, with 30 mg, 60 mg, 90 mg, 120 mg, and 180 mg daily doses till the targeted iPTH range level is 150-300 pg/mL. Level measurement of serum iPTH should be taken no less than 12 hours after dosing with Cinacalcet.
Patients with Parathyroid Carcinoma and Primary Hyperparathyroidism: The recommended starting oral dose of Cinacalcet is 30 mg twice daily. The dose of Cinacalcet should be titrated every 2 to 4 weeks through sequential doses of 30 mg twice daily, 60 mg twice daily, 90 mg twice daily, and 90 mg 3 or 4 times daily as necessary to normalize serum calcium levels. Serum calcium should be measured within 1 week after initiation or dose adjustment of Cinacalcet.