Polivy (Polatuzumab vedotin), which targets a protein known as CD79b is used in treating patients with specific types of lymphoma, particularly Diffuse Large B-cell lymphoma (DLBCL) and High-Grade B-cell lymphoma (HGBL). When combined with other medicinal products like rituximab, cyclophosphamide, doxorubicin, and prednisone (known as R-CHP) or with bendamustine and rituximab (BR), Polivy is prescribed to adult patients under certain conditions. Patients new to treatment or those who haven’t responded to at least two prior treatments may benefit from this therapy.
Administered as an IV infusion, this therapeutic drug helps block a protein (CD79b), found on lymphoma cells, which allows it to directly target and destroy these cells. This focused approach has brought hope to many patients, but it also carries some important safety considerations and potential side effects that patients must be aware of.
Primary Indications of Polivy:
This therapeutic drug is used in two main treatment scenarios for lymphoma patients:
- Untreated DLBCL or HGBL Patients with High Risk: Polivy combined with R-CHP may be recommended for adults with newly diagnosed DLBCL or HGBL, especially those with higher prognostic scores. The combination therapy aims to curb cancer spread early in the treatment journey.
- Relapsed or Refractory DLBCL Patients: For patients who have relapsed or haven’t responded to two previous treatments, Polivy can be combined with BR therapy to offer another therapeutic avenue.
Common Side Effects of Polivy:
Polivy can cause several side effects, varying depending on its combination. The most common side effects (occurring in over 20% of patients) are:
With R-CHP: Peripheral neuropathy, nausea, fatigue, diarrhea, constipation, hair loss, and mouth sores.
With BR: Anemia, neutropenia, thrombocytopenia, fatigue, decreased appetite, diarrhea, fever, and pneumonia.
Important Safety Information:
Patients undergoing Polivy therapy should be monitored for several key health concerns:
- Peripheral Neuropathy: Often appearing early in treatment, this condition affects nerves and may worsen over time. Patients may experience numbness, tingling, or weakness, especially in their hands and feet. Report any of these symptoms to your doctor promptly.
- Infusion-Related Reactions: Symptoms such as chills, breathing difficulty, fever, or chest discomfort can occur within 24 hours post-infusion. Doctors typically administer antihistamines and fever-reducing medication before Polivy to minimize these reactions.
- Myelosuppression: Low counts of neutrophils, platelets, or red blood cells can occur, requiring regular blood tests. In some cases, additional medications may be given to support blood cell levels.
- Serious Infections: Polivy users may be vulnerable to severe infections, including sepsis, pneumonia, and viral infections like cytomegalovirus. Preventive measures, including medications for pneumonia and herpesvirus, are often recommended to manage this risk.
- Progressive Multifocal Leukoencephalopathy (PML): A rare but serious brain infection called PML has been reported in patients using Polivy with bendamustine. If you notice any mental or behavioral changes, seek medical advice promptly.
- Tumor Lysis Syndrome: Patients with high cancer cell counts may experience a breakdown of tumor cells, leading to serious metabolic issues. Doctors may provide medication to prevent this syndrome.
- Liver Problems: Severe liver issues have been reported in some Polivy users, especially those with pre-existing liver conditions or high baseline enzyme levels. Regular liver tests can help detect any concerns early.
- Embryo-Fetal Risks: This therapeutic drug may harm an unborn baby, so women of childbearing age should use reliable contraception during and up to three months after treatment. Male patients should also use contraception for five months post-treatment to prevent pregnancy risks.
Additional Information on Polivy Treatment Monitoring:
For patients undergoing Polivy treatment, regular check-ups, including blood tests and scans, help monitor the treatment’s impact. Open communication with healthcare providers about any side effects or symptoms is crucial to ensure safe and effective care. Regular tests, such as complete blood counts (CBC), liver function tests, and neurological assessments, provide early insights into any side effects and allow for timely interventions.
Frequently Asked Questions (FAQs):
What types of cancer does Polivy treat?
Polivy is used for treating Diffuse Large B-cell lymphoma (DLBCL) and High-Grade B-cell lymphoma (HGBL), either as first-line therapy with R-CHP or in relapsed cases with BR therapy.
How long does Polivy treatment last?
Polivy treatment cycles vary based on patient response and type of lymphoma. Typically, a cycle lasts 21 days, but your doctor will decide the ideal treatment duration.
What should I do if I experience numbness or tingling in my hands or feet?
Peripheral neuropathy is a common side effect of Polivy. Inform your healthcare provider if you notice numbness, tingling, or weakness in your extremities, as these may require adjustments in your treatment.
Can Polivy cause liver issues?
Yes, some patients may experience liver problems while on treatment with this medicine. Routine liver tests help monitor this. Notify your doctor if you notice symptoms like yellowing of the skin or eyes, as these may indicate liver issues.
How can I buy Polivy in India?
You can buy Polivy in India through authorized suppliers that facilitate access to medicines not readily available in local markets. It’s important to work with licensed providers to ensure you receive genuine Polivy for safe and effective treatment.
Is Polivy available for delivery outside of India?
Yes, certain providers in India facilitate the legal supply of Polivy to other countries where it may not be available. Indian Pharma Network (IPN) can help arrange global supply with the necessary documentation.
Can I buy Polivy online in India?
Polivy can be accessed through trusted suppliers specializing in oncology medicines. However, it’s essential to ensure the platform is reputable and complies with medical regulations for safe purchasing.
What is the cost of buying Polivy in India?
The price of Polivy in India may vary based on the source and any import duties or fees. For precise pricing and assistance, you can contact Indian Pharma Network (IPN) at Call/WhatsApp: +91 9310090915 to receive the latest information on availability and cost.
Conclusion:
Polivy offers a promising option for patients battling certain forms of lymphoma, particularly DLBCL, and HGBL when used with other therapies. While it presents specific side effects and safety precautions, regular monitoring, open communication with healthcare providers, and adherence to prescribed precautions can make Polivy a valuable part of cancer treatment. Always consult with your doctor for personalized guidance throughout your Polivy treatment journey, and if any concerns arise, reach out to your healthcare team immediately.
