Orlynvah (Sulopenem Etzadroxil and Probenecid)

Orlynvah is a combination of sulopenem etzadroxil (a penem antibacterial) and probenecid (a renal tubular transport inhibitor). It is used for the treatment of uncomplicated urinary tract infections (uUTI) developed by microorganisms Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis in adult women who have limited or no other oral antibacterial therapeutic options.

Limitations of Use: Orlynvah (sulopenem etzadroxil and probenecid) is not used for the treatment of:

• Complicated urinary tract infections (cUTI) or step-down treatment after IV antibacterial treatment of cUTI.
• Complicated intra-abdominal infections (cIAI) or step-down treatment after IV antibacterial treatment of cIAI.

Recommended Dosage: The recommended dosage is one tablet (sulopenem etzadroxil 500 mg and probenecid 500 mg) taken orally twice daily for 5 days. Take the recommended dosage with food. Do not administer this medicine in patients with creatinine clearance (CrCL) below 15 mL/min or patients on hemodialysis. Dosage adjustment is not required in patients with CrCL more than or equal to 15 mL/min.

If a dose is missed, patients should take the dose as quickly as possible. Do not double the dose to make up for the missed dose.

• Sulopenem Etzadroxil and Probenecid may cause serious hypersensitivity reactions, including anaphylaxis. Stop treatment promptly if symptoms like rash, breathing difficulty, or swelling arise. Patients with known beta-lactam allergies or with a history of hypersensitivity to penicillins or cephalosporins should this medicine.
• The use of antibacterial may cause CDAD which may range from mild diarrhea to serious colitis. Assess patients for signs and symptoms during and after therapy. If CDAD is noticed, interrupt treatment and start suitable fluid replacement and antimicrobial therapy.
• Probenecid 500 mg in Orlynvah may increase the probability of uric acid kidney stones. Maintain enough hydration to reduce the risk. Assess patients with a known history of kidney stones and advise lifestyle modifications to help prevent recurrence during treatment.
• Probenecid may cause gout symptoms worse by affecting uric acid excretion. Use it with caution in individuals with gout. Uric acid levels should monitored. Consider alternative therapies if gout symptoms worsen during treatment.
• If Sulopenem Etzadroxil and Probenecid is not used appropriately, it may promote the growth of drug-resistant bacteria. Use this treatment only for approved indications and finish the complete course of treatment as prescribed to reduce the chance of resistance development.
• The safety of this medicine during pregnancy is not well established. Use it only if the potential benefit justifies the risk to the fetus. Consult doctors before initiating treatment in those who are pregnant or those planning pregnancy.
• Components in Orlynvah may be excreted in breast milk which may causee side effects in nursing infants. Breastfeeding is not recommended during treatment or consult healthcare providers for alternative therapies on behalf of clinical necessity.

What documents are required to import ORLYNVAH to India?

ORLYNVAH (sulopenem etzadroxil and probenecid) tablets can be imported by patients or government hospitals in the name of the patients only.

The following documentation is required to import the product:

• A valid prescription from a qualified doctor.
• Patients diagnostic reports
• Patient ID proof (issued by the government of India)

How does the order be confirmed?

The order will be confirmed only after the receipt of:

• A valid prescription from the Doctor
• Import permit if applicable

Is ORLYNVAH available in India?

ORLYNVAH (sulopenem etzadroxil and probenecid tablets) is a (prescription drug, prescription medication, or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.

IPN (Indian Pharma Network) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is the facilitator providing input

• On availability of Orlynvah in India (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Pune etc.)
• On availability in Gulf countries (Bahrain, Oman, Qatar, Kuwait, Iraq, Saudi Arabia, and the UAE).
• Medicine Price.
• Finding Genuine and reliable sources from the USA, Canada,
• Europe, and Australia
• Ensuring 100% transparency.

ORLYNVAH can be made available to patients, doctors, and hospitals in Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow, and Pune and other cities in India. The order will be confirmed only after the receipt of a valid prescription from the doctor and an import permit.

IPN (Indian Pharma Network) can facilitate the supply of ORLYNVAH (prescription medicines) to all locations in the world and India after fulfilling the legal requirement (if applicable).

Please contact +91-9310090915 | Toll-Free Number: 1800-889-1064 or write us at info@indianpharmanetwork.in for Orlynvah tablet prices in India.

We guarantee quality and delivery anywhere in the world as per the buyer’s requirements.

Indian Pharma Network can source the ORLYNVAH (Cancer Treatment Medicines) from across the globe and can supply. Indian Pharma offers its customers worldwide access to the best available treatment.

Indian Pharma Network (IPN) can dispense any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the Patient's address only from New Delhi, India.

What is the Generic Name for the trade name drug Orlynvah®?

Sulopenem Etzadroxil and Probenecid is a Generic Name for the trade name drug Orlynvah®.

What is the Manufacturer's Name of Orlynvah®?

Orlynvah® is manufactured by Iterum Therapeutics.

Is Orlynvah® approved by the FDA?

Yes, Orlynvah® is approved by the FDA. Date of first approval: October 25, 2024.

What is the dosage and form of Orlynvah® supplied?

Orlynvah® is supplied tablets: 500 mg sulopenem etzadroxil and 500 mg probenecid for oral use.

What are the most common side effects of Orlynvah®?

The most common side effects of Orlynvah® are diarrhea, vulvovaginal mycotic infection, headache, nausea, and vomiting.

How much does Orlynvah® (Sulopenem Etzadroxil and Probenecid) Tablets cost in India?

Prices of Orlynvah may fluctuate over time due to market dynamics and regulatory changes. To get the accurate and latest information on Orlynvah 500 mg/500 mg cost in India, kindly Call/WhatsApp +91-9310090915 or send mail to info@indianpharmanetwork.in.

Can Orlynvah® be available in SAARC countries?

Apart from Gulf countries, Orlynvah® can be available in SAARC countries (India, Afghanistan, Maldives, Nepal, Bangladesh, Bhutan, Pakistan, and Sri Lanka). Indian Pharma Network (IPN) can help facilitate the supply of Orlynvah® Tablets in these countries, ensuring access to this therapeutic drug through legal and reliable channels.

Is it safe to buy Orlynvah® Tablets online in India?

Yes, one can buy Orlynvah tablets online in India at the lowest price from the Indian Pharma Network (IPN) if this medicinal product is not (yet) registered or available in their country. We can help facilitate the supply of Orlynvah® Tablets through legal channels.

What are the storage conditions of Orlynvah® Tablets?

Store this therapeutic drug at 20 to 25°C (68 to 77°F); excursions permitted to 15 to 30°C (59°F to 86°F).