Medical Uses
Nulojix (belatacept) is a selective T-cell costimulation blocker used for prophylaxis of organ rejection in adult patients receiving a kidney transplant. This therapeutic drug is used together with basiliximab induction, mycophenolate mofetil, and corticosteroids.
Limitations of Use: Use this therapeutic drug only in those who are EBV seropositive. Its use has not been evaluated for the prophylaxis of organ rejection in transplanted organs other than the kidney.
Recommended Dosage: The recommended dosage of Nulojix 250 mg injection is administered in combination with basiliximab induction, mycophenolate mofetil (MMF), and corticosteroids. It is intravenous (IV) infusion only
Usual Adult Dose for Rejection Prophylaxis:
- Initial phase dose: The recommended initial phase dose is 10 mg/kg IV on Day 1 (day of transplant, before implantation) and Day 5 (approximately 96 hours after Day 1 dose), and at the end of Weeks 2, 4, 8, and 12 after transplantation.
- Maintenance phase dose: The recommended maintenance phase dose is 5 mg/kg IV at the end of Week 16 after transplantation and every 4 weeks (plus or minus 3 days) thereafter.
Usual Adult Dose for Renal Transplant:
- Initial phase dose: The recommended initial phase dose is 10 mg/kg IV on Day 1 (day of transplant, before implantation) and Day 5 (approximately 96 hours after Day 1 dose), and at the end of Weeks 2, 4, 8, and 12 after transplantation.
- Maintenance phase dose: The recommended maintenance phase dose is 5 mg/kg IV at the end of Week 16 after transplantation and every 4 weeks (plus or minus 3 days) thereafter.