Medical Uses
Hympavzi (marstacimab-hncq) is a tissue factor pathway inhibitor (TFPI) antagonist used for the prevention or reduction of the frequency of bleeding episodes in adult and pediatric patients aged 12 years and older with hemophilia A (congenital factor VIII deficiency) without factor VIII inhibitors, or hemophilia B (congenital factor IX deficiency) without factor IX inhibitors.
Recommended Dosage: The recommended loading dose is 300 mg (two 150 mg SC injections). In case more than one injection is needed to deliver a complete dose, consider different injection sites for administering each injection. After one week of the loading dose, start maintenance dosing of 150 mg administered every week by SC injection on the same day each week, at any time of day.
Adjust the dose to 300 mg SC injection weekly in patients weighing more than or equal to 50 kg when control of bleeding events is judged to be inadequate by the clinician. The safety and efficacy of therapy at doses beyond 300 mg weekly have not been assessed. If more than one injection is needed to deliver a complete dose, consider administering each injection at a different injection site.