Grafapex (treosulfan)

Grafapex (treosulfan) is an alkylating drug used in combination with fludarabine as a preparative regimen for allogeneic hematopoietic stem cell transplantation in adult and pediatric patients aged 1 year and older with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).

Recommended Dosage: The recommended dose of Grafapex is 10 g/m² body surface area (BSA) per day as a two-hour intravenous (IV) infusion. Administer the prescribed dosage on three consecutive days (day -4, -3, -2) in conjunction with fludarabine before hematopoietic stem cell infusion (day 0).
Premedicate patients with antiemetics before the first dose of Treosulfan and continue antiemetics on a fixed schedule through the end of treosulfan administration.

• The use of Grafapex can lead to the severing of bone marrow, which will ultimately result in a decrease in blood cell production. This will increase the chances of infection, anemia, and bleeding. Routine blood examinations are necessary to assess white blood cells, platelets, and hemoglobin amounts throughout the process of receiving treatment.
• In patients with a history of seizures or any neurological conditions, Grafapex has the potential to induce seizure episodes. In such occurrences careful supervision is essential and dosage needs to be modified during such instances. It is advised to refrain from activities that need one’s full attention like driving and operating heavy machinery during this phase of treatment.
• Along with several other issues, Grafapex can cause skin problems like rashes, turning the skin red with blisters, peeling skin, and blisters. Seeking medical attention is absolutely necessary if symptoms like painful rashes, itching, or inflammation arise. Such patients should avoid too much sun exposure and if possible use protective wear or sunscreen.
• If utilized for a long period, secondary cancers could develop - such as leukemia or lymphoma. With the repetition of this medicine, the chances of such happening do increase. It is wise to get regular doctor checkups and tests for cancers. Make sure to mention if you notice anything unusual to your medical professional like fevers that do not seem to go away, sudden change in weight, or bruising without a reason.
• This medicine may lead to pain, tenderness, redness, swelling, or even necrosis of the tissue at the site of injection. Burning, blistering, or extreme pain should be adequately reported. As with most medications, proper ‘technique’ as well as rotation of sites will reduce these effects.
• Use of this therapeutic drug during pregnancy can cause harm baby. Women of childbearing age need to use sufficient contraception whilst undergoing treatment and should seek medical assistance if they become pregnant. Male patients should equally take necessary precautions as it is believed to affect spermatogenesis.
• There is a possibility that the medicine will be transferred to breast milk and therefore has the potential to harm the child. Women should stop breastfeeding while on treatment and for a sufficient period thereafter as guided by their physician. Consult with your doctor for other alternatives.

What documents are required to import GRAFAPEX to India?

GRAFAPEX (treosulfan) injections can be imported by patients or government hospitals on the name of the patients only.
The following documentation is required to import the product:

• A valid prescription from a qualified doctor.
• Patients diagnostic reports
• Patient ID proof (issued by the government of India)

How does the order be confirmed?

The order will be confirmed only after the receipt of:

• A valid prescription from the Doctor
• Import permit if applicable

Is GRAFAPEX available in India?

GRAFAPEX (treosulfan injections) is a (prescription drug, prescription medication, or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.

IPN (Indian Pharma Network) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is the facilitator providing input

• On availability of Grafapex in India (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Pune etc.)
• On availability in Gulf countries (Bahrain, Oman, Qatar, Kuwait,
• Iraq, Saudi Arabia, and the UAE).
• Medicine Price.
• Finding Genuine and reliable sources from the USA, Canada, Europe, and Australia
• Ensuring 100% transparency.

GRAFAPEX can be made available to patients, doctors, and hospitals in Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow, and Pune and other cities in India. The order will be confirmed only after the receipt of a valid prescription from the doctor and an import permit.

IPN (Indian Pharma Network) can facilitate the supply of GRAFAPEX (prescription medicines) to all locations in the world and India after fulfilling the legal requirement (if applicable).

Please contact +91-9310090915 | Toll-Free Number: 1800-889-1064 or write us at info@indianpharmanetwork.in for Grafapex 1 g/5 g price in India.

We guarantee quality and delivery anywhere in the world as per the buyer’s requirements.

Indian Pharma Network can source GRAFAPEX (Cancer Treatment Medicines) from across the globe and can supply. Indian Pharma offers its customers worldwide access to the best available treatment.

Indian Pharma Network (IPN) can dispense any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the Patient's address only from New Delhi, India.

What is the Generic Name for the trade name drug Grafapex®?

Treosulfan is a Generic Name for the trade name drug Grafapex®.

What is the Manufacturer's Name of Grafapex®?

Grafapex® is manufactured by Medexus Pharmaceuticals Inc.

Is Grafapex approved by the FDA?

Yes, Grafapex® is approved by the FDA. Date of first approval: January 21, 2025.

What is the dosage and form of Grafapex® supplied?

Grafapex is supplied for injection: 1 g/vial and 5 g/vial treosulfan as a lyophilized powder in a single-dose vial for intravenous (IV) use.

What are the most common side effects of Grafapex® 1 g/5 g injections?

The most common side effects of Grafapex® 1 g/5 g injections are nausea,, musculoskeletal pain, edema, stomatitis, pyrexia, infection, and vomiting.

How much does Grafapex® 1 g/5 g injections cost in India?

Prices of Grafapex 1 g/5 g injections may fluctuate over time because of market dynamics and regulatory changes. For the most transparent and latest Grafapex 1 g/5 g injection cost in India, please Call/WhatsApp +91-9310090915 or send mail to info@indianpharmanetwork.in.

Can Grafapex® 1 g/5 g injections be available in SAARC countries?

Apart from Gulf countries, Grafapex® can be available in SAARC countries (India, Afghanistan, Maldives, Nepal, Bangladesh, Bhutan, Pakistan, and Sri Lanka). Indian Pharma Network (IPN) can help facilitate the legal supply of Grafapex® injections in these countries. We help ensure legal access to this therapeutic drug through our reliable channels.

Is it safe to buy Grafapex® 1 g/5 g injections online in India?

Yes, one can buy Grafapex 1 g/5 g online in India at the lowest price from the Indian Pharma Network (IPN) if this medicinal product is not (yet) registered or available in their country. We can help facilitate the legal supply of Grafapex® injections through legal channels.

What are the storage conditions of Grafapex® 1 g/5 g injections?

Store 1 g/5 g vials at 20°C to 25°C (68°F to 77°F). Excursions permitted between 15°C and 30°C.