Zevtera (Ceftobiprole Medocaril)

Zevtera® (ceftobiprole medocaril) is a broad-spectrum cephalosporin antibiotic used primarily against complex bacterial infections. It is used for the treatment of

• adult patients with Staphylococcus aureus bloodstream infections (bacteremia) (SAB), including those with right-sided infective endocarditis.
• adult patients with acute bacterial skin and skin structure infections (ABSSSI)
• adult and pediatric patients (aged 3 months to less than 18 years) with community-acquired bacterial pneumonia (CABP).

Recommended Dosage: The recommended dosage of Zevtera for adult patients with SAB, ABSSSI and CABP is as follows:

• SAB: The recommended dose is 667 mg administered every 6 hours on Days 1 to 8 then every 8 hours from Day 9
  
• ABSSSI: The recommended dose is 667 mg administered every 8 hours 
  
• CABP: The recommended dose is 667 mg administered every 8 hours 

Duration of therapy in adults is up to 42 days for SAB and 5-14 days for ABSSSI and CABP.  Administer each prepared intravenous infusion solution over 2 hours at a concentration of 2.67 mg/mL.

The recommended dosage of Zevtera for pediatric patients (aged 3 months to less than 18 years) with CABP is as follows:

• Pediatric Patients Aged 12 Years to Less than 18 Years Old: The recommended dose is 13.3 mg/kg (up to 667 mg/dose) administered every 8 hours 
  
• Pediatric Patients Aged Greater than or Equal to 3 Months and Less than 12 Years Old: The recommended dose is 20 mg/kg (up to 667 mg/dose) administered every 8 hours.

• Patients with a known allergy to ceftobiprole, cephalosporins, or any beta-lactam antibiotics should avoid using Zevtera injection. Hypersensitivity reactions, including severe anaphylaxis, can occur. Immediate medical attention is necessary if an allergic reaction develops.
  
• Antibiotic treatment can alter the normal flora of the colon and permit the overgrowth of Clostridium difficile. This may result in severe diarrhea. If CDAD is suspected, appropriate measures, such as discontinuation of the antibiotic, should be taken.
  
• The prolonged use of antibiotics can lead to the overgrowth of non-susceptible organisms. Continuous monitoring is advised, and if a superinfection occurs, appropriate measures should be implemented.
  
• Dosage adjustments are required for patients with moderate to severe renal impairment. Regular monitoring of renal function is recommended to avoid potential toxicity.
  
• Patients should be monitored for signs of hematologic reactions such as neutropenia, thrombocytopenia, or anemia. Regular blood counts are advisable, particularly during prolonged therapy. 
  
• To minimize the development of drug-resistant bacteria, Ceftobiprole Medocaril should be used only to treat infections that are confirmed or strongly suspected to be caused by susceptible bacteria. Prescribing it in the absence of a confirmed bacterial infection increases the risk of resistance.
  
• Safety and efficacy in pediatric patients have not been established. Pregnant and breastfeeding women should only use Zevtera if clearly needed, and after a thorough evaluation of the potential risks and benefits.
  

What documents are required to import ZEVTERA to India?

ZEVTERA (ceftobiprole medocaril) injections can be imported by patients or government hospitals on the name of the patients only. 

The following documentation is required to import the product:

• A valid prescription from a qualified doctor.
  
• Patients diagnostic reports
  
• Patient ID proof (issued by the government of India)

The order will be confirmed only after the receipt of:

• A valid prescription from the Doctor
  
• Import permit if applicable

ZEVTERA (ceftobiprole medocaril injections) is a (prescription drug, prescription medication, or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.

IPN (Indian Pharma Network) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is the facilitator providing input

• On availability of Zevtera in India (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Pune etc.)
  
• Medicine Price.
  
• Finding Genuine and reliable sources from the USA, Canada, Europe, and Australia
  
• Ensuring 100% transparency.

IPN (Indian Pharma Network) can facilitate the supply of ZEVTERA (prescription medicines) to all locations in the world and in India after fulfilling the legal requirement (if applicable).

Please contact +91-9310090915 | Toll-Free Number: 1800-889-1064 or write us at info@indianpharmanetwork.in for Zevtera injection price in India. 

We take to guarantee quality and delivery anywhere in the world as per the buyer’s requirements.

Indian Pharma Network is able to source the ZEVTERA (Cancer Treatment Medicines) from across the globe and has the ability to supply. Indian Pharma offers its customers worldwide access to the best available treatment.

Indian Pharma Network is able to dispense any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the Patient’s address only from New Delhi, India.

What is the Generic Name for the trade name drug Zevtera®?

Ceftobiprole Medocaril is a Generic Name for the trade name drug Zevtera®.

What is the Manufacturer’s Name of Zevtera®?

Zevtera® is manufactured by Basilea Pharmaceutica Ltd.

Is Zevtera® approved by the FDA?

Yes, Zevtera® is approved by the FDA. Date of first approval: April 3, 2024.

What is the dosage and form of Zevtera® supplied?

Zevtera® is supplied for injection: 667 mg of ceftobiprole medocaril sodium (equivalent to 500 mg of ceftobiprole) as a lyophilized powder for reconstitution in a single-dose vial for intravenous (IV) use. 

What are the most common side effects of Zevtera®? 

The most common side effects of Zevtera® are nausea, diarrhea, headache, rash, and elevated liver enzymes.

How much does Zevtera® cost in India?

Prices may fluctuate over time due to market dynamics and regulatory changes. To obtain accurate and up-to-date information on the cost of Zevtera in India, it is recommended to Call/WhatsApp +91-9310090915 or send mail to info@indianpharmanetwork.in.

What are the storage conditions of Zevtera®?

Zevtera® should be stored at room temperature, between 20°C to 25°C (68°F to 77°F). Protect it from light and moisture, and keep it in its original packaging until use.

Is it safe to buy Zevtera® online in India?

Yes, one can buy Zevtera online in India at the lowest price from the Indian Pharma Network (IPN) if this medicinal product is not (yet) registered or available in the country. We can help facilitate the supply of Zevtera® through legal channels.